Nociceptin/orphanin FQ peptide receptor mediates inhibition of N-type calcium currents in vestibular afferent neurons of the rat-Reference-Cited by-同舟云学术

Nociceptin/orphanin FQ peptide receptor mediates inhibition of N-type calcium currents in vestibular afferent neurons of the rat

Published:2020-12-01 Issue:6 Volume:124 Page:1605-1614
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Seseña Emmanuel¹^ORCID,Soto Enrique²^ORCID,Bueno Jesua²^ORCID,Vega Rosario²^ORCID

Affiliation:

1. Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Pue, México

2. Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Pue, México

Abstract

Our results show that in primary vestibular afferent neurons, activation of the nociceptin/orphanin FQ peptide receptor inhibits the N-type calcium current by a mechanism mediated by G proteins. We propose that calcium current inhibition modulates neurotransmitter release from vestibular afferents, producing a presynaptic modulation of vestibular input to vestibular nuclei, thus contributing to gain control in the vestibular afferent input.

Funder

Consejo Nacional de Ciencia y Tecnología

Vicerrectoria de Investigación y Estudios de Posgrado

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00269.2020

Reference53 articles.

1. ORL1 receptor–mediated internalization of N-type calcium channels

2. Vestibular System: The Many Facets of a Multimodal Sense