Molecular insights using spatial transcriptomics of the distal lung in congenital diaphragmatic hernia-Reference-Cited by-同舟云学术

Molecular insights using spatial transcriptomics of the distal lung in congenital diaphragmatic hernia

Published:2023-10-01 Issue:4 Volume:325 Page:L477-L486
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Lingappan Krithika¹^ORCID,Olutoye Oluyinka O.²,Cantu Abiud¹^ORCID,Cantu Gutierrez Manuel Eliezer¹^ORCID,Cortes-Santiago Nahir³^ORCID,Hammond J. D.⁴,Gilley Jamie⁴,Quintero Joselyn Rojas⁵,Li Hui²,Polverino Francesca⁵,Gleghorn Jason P.⁶^ORCID,Keswani Sundeep G.²

Affiliation:

1. Division of Neonatology, Department of Pediatrics, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, United States

2. Department of Pediatric Surgery, Baylor College of Medicine, Texas Children’s Hospital, Houston, Texas, United States

3. Department of Pathology, Baylor College of Medicine, Texas Children’s Hospital, Houston, Texas, United States

4. Division of Neonatology, Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, Houston, Texas, United States

5. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Baylor College of Medicine, Houston, Texas, United States

6. Department of Biomedical Engineering, University of Delaware, Newark, Delaware, United States

Abstract

This is the first use of spatial transcriptomics in patients with congenital diaphragmatic hernia (CDH) that identifies the contribution of different lung cellular subpopulations in CDH pathophysiology and highlights sex-specific differences.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Child Health and Human Development

Publisher

American Physiological Society

Subject

Cell Biology,Physiology (medical),Pulmonary and Respiratory Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00154.2023

Reference49 articles.

1. Congenital diaphragmatic hernia: The hidden mortality

2. The hidden mortality of congenital diaphragmatic hernia: a 20-year review