Mesenchymal stromal cell extracellular vesicles improve lung development in mechanically ventilated preterm lambs-Reference-Cited by-同舟云学术

Mesenchymal stromal cell extracellular vesicles improve lung development in mechanically ventilated preterm lambs

Published:2024-06-01 Issue:6 Volume:326 Page:L770-L785
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Albertine Kurt H.¹^ORCID,Rebentisch Andrew¹^ORCID,Dawson Elaine¹,Van Boerum Jakob¹,Major Emily¹,Štipka Juraj¹,Foreman Hannah¹,Headden David¹,Vordos Zoë¹,Beck Emily¹,Wang Zhengming¹,Yang Haixia¹,Yu Baifeng¹,Dahl Mar Janna¹^ORCID,Null Donald M.¹,Bizzotto Davide²^ORCID,Veneroni Chiara²^ORCID,Lavizzari Anna³^ORCID,Dellacà Raffaele L.²^ORCID,Delavogia Eleni⁴,Mitsialis S. Alex⁴,Kourembanas Stella⁴^ORCID

Affiliation:

1. Division of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States

2. TechRes Lab, Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano University, Milan, Italy

3. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

4. Division of Neonatology, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States

Abstract

This study focused on potential treatment of preterm infants at risk of developing bronchopulmonary dysplasia (BPD), for which no effective treatment exists. We tested treatment of mechanically ventilated preterm lambs with human mesenchymal stromal cell extracellular vesicles (MSC-sEVs). The results show improved respiratory gas exchange and parenchymal growth of capillaries and epithelium that are necessary for alveolar formation. Our study provides new mechanistic insight into potential efficacy of MSC-sEVs for preterm infants at risk of developing BPD.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

United Therapeutics Corporation

Boston Children’s Hospital

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00349.2023

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