Cell-free hemoglobin triggers macrophage cytokine production via TLR4 and MyD88-Reference-Cited by-同舟云学术

Cell-free hemoglobin triggers macrophage cytokine production via TLR4 and MyD88

Published:2024-01-01 Issue:1 Volume:326 Page:L29-L38
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Schaaf Kaitlyn R.¹²^ORCID,Landstreet Stuart R.¹,Pugazenthi Sangami¹,Qian Emily Y.¹,Putz Nathan D.¹,Siderova Tatiana¹,Owen Allison M.³^ORCID,Bohannon Julia K.²³,Ware Lorraine B.¹²^ORCID,Bastarache Julie A.¹²⁴^ORCID,Shaver Ciara M.¹^ORCID

Affiliation:

1. Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States

2. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States

3. Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States

4. Department of Cell and Molecular Biology, Vanderbilt University, Nashville, Tennessee, United States

Abstract

Cell-free hemoglobin (CFH) is elevated in the airspace of most patients with acute respiratory distress syndrome and causes severe inflammation. Here, we identify that CFH contributes to macrophage-induced cytokine production via Toll-like receptor 4 (TLR4) and myeloid differentiation primary response 88 (MyD88) signaling. These data increase our knowledge of the mechanisms through which CFH contributes to lung injury and may inform development of targeted therapeutics to attenuate inflammation.

Funder

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of General Medical Sciences

U.S. Department of Defense

U.S. Department of Veterans Affairs

Vanderbilt University

Publisher

American Physiological Society

Subject

Cell Biology,Physiology (medical),Pulmonary and Respiratory Medicine,Physiology

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