A pro-con debate: current controversies in PAH pathogenesis at the American Thoracic Society International Conference in 2017

Author:

Kuebler Wolfgang M.1234,Nicolls Mark R.5,Olschewski Andrea67,Abe Kohtaro8,Rabinovitch Marlene9,Stewart Duncan10,Chan Stephen Y.11ORCID,Morrell Nicholas W.12,Archer Stephen L.13,Spiekerkoetter Edda5

Affiliation:

1. Institute of Physiology, Charité-Universitaetsmedizin Berlin, Berlin, Germany

2. Keenan Research Centre for Biomedical Science at Saint Michael’s, Toronto, Ontario, Canada

3. Department of Surgery, University of Toronto, Toronto, Ontario, Canada

4. Department of Physiology, University of Toronto, Toronto, Ontario, Canada

5. Division of Pulmonary and Critical Care, Department of Medicine, Wall Center for Pulmonary Vascular Disease, Cardiovascular Institute, Stanford University, Stanford, California

6. Ludwig Boltzmann Institute, Lung Vascular Research, Medical University of Graz, Graz, Austria

7. Johannes Kepler University Linz, Medicine Rectorate, Linz, Austria

8. Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan

9. Division of Cardiology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California

10. Division of Cardiology, Department of Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

11. Division of Cardiology, Department of Medicine, Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

12. Division of Respiratory Medicine, Department of Medicine, University of Cambridge School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom

13. Department of Medicine, Queen’s University, Kingston, Ontario, Canada

Abstract

The following review summarizes the pro-con debate about current controversies regarding the pathogenesis of pulmonary arterial hypertension (PAH) that took place at the American Thoracic Society Conference in May 2017. Leaders in the field of PAH research discussed the importance of the immune system, the role of hemodynamic stress and endothelial apoptosis, as well as bone morphogenetic protein receptor-2 signaling in PAH pathogenesis. Whereas this summary does not intend to resolve obvious conflicts in opinion, we hope that the presented arguments entice further discussions and draw a new generation of enthusiastic researchers into this vibrant field of science to bridge existing gaps for a better understanding and therapy of this fatal disease.

Funder

Heart and Stroke Foundation of Canada (HSFC)

Deutsche Forschungsgemeinschaft (DFG)

DZHK

DZL

ORF SCORR

NHLBI

NHI

American Heart Association (AHA)

DJS

OeNB

OeAD

Austrian Science Fund (FWF)

Japan Society for the Promotion of Science (JSPS)

Ontario Research Excellence Fund

British Heart Foundation (BHF)

CIHR Foundation Grant

NIH

Tier 1 Canada Research Chair in Mitochondrial Dynamics

The William Henderson Foundation

CIHR Vascular Network

Canadian Vascular Network

Department of Defense

Wall Center For Pulmonary Vascular Disease Stanford

Pulmonary Hypertension Association (PHA)

Publisher

American Physiological Society

Subject

Cell Biology,Physiology (medical),Pulmonary and Respiratory Medicine,Physiology

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