Sphingosine kinase 1-specific inhibitor PF543 reduces goblet cell metaplasia of bronchial epithelium in an acute asthma model-Reference-Cited by-同舟云学术

Sphingosine kinase 1-specific inhibitor PF543 reduces goblet cell metaplasia of bronchial epithelium in an acute asthma model

Published:2024-03-01 Issue:3 Volume:326 Page:L377-L392
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Sudhadevi Tara¹^ORCID,Ackerman Steven J.²,Jafri Anjum³,Basa Prathima¹,Ha Alison W.²,Natarajan Viswanathan⁴⁵,Harijith Anantha¹^ORCID

Affiliation:

1. Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States

2. Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, United States

3. Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States

4. Department of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, Illinois, United States

5. Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States

Abstract

The role of SPHK1-specific inhibitor, PF543, in preventing goblet cell metaplasia (GCM) and airway hyperreactivity (AHR) is established in an allergen-induced mouse model. This protection was associated with the downregulation of NOTCH2-SPDEF signaling pathway, suggesting a novel link between SPHK1, GCM, and AHR.

Funder

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00269.2023

Reference77 articles.

1. Overlap of atopic, eosinophilic, and TH2-high asthma phenotypes in a general population with current asthma

2. Efficacy of Biologics in Patients with Allergic Severe Asthma, Overall and by Blood Eosinophil Count: A Literature Review

3. The Allergic Asthma Phenotype

4. Increased prevalence of allergic asthma from 1996 to 2006 and further to 2016-results from three population surveys

5. 2023 GINA report for asthma