Affiliation:
1. Department of Medicine, University of California, San Francisco, California, United States
Abstract
Many lung research studies involve dosing fluids into lungs of mice. In this study, the authors measure lung deposition using intranasal (i.n.), oropharyngeal aspiration (o.a.), and intratracheal (i.t.) dosing methods in mice. Anesthetic approach and administration route were found to affect pulmonary dosing efficiency. The authors demonstrate that refinements to dosing techniques can enable reductions in the number of animals needed for bacterial and viral pneumonia studies.
Funder
AABB
American Society of Transplantation
HHS | National Institutes of Health
International Anesthesia Research Society
Sandler Foundation
Publisher
American Physiological Society
Subject
Cell Biology,Physiology (medical),Pulmonary and Respiratory Medicine,Physiology
Cited by
1 articles.
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