Optimizing anesthesia and delivery approaches for dosing into lungs of mice

Author:

Seo Yurim1,Qiu Longhui1,Magnen Mélia1,Conrad Catharina1,Moussavi-Harami S. Farshid1,Looney Mark R.1ORCID,Cleary Simon J.1ORCID

Affiliation:

1. Department of Medicine, University of California, San Francisco, California, United States

Abstract

Many lung research studies involve dosing fluids into lungs of mice. In this study, the authors measure lung deposition using intranasal (i.n.), oropharyngeal aspiration (o.a.), and intratracheal (i.t.) dosing methods in mice. Anesthetic approach and administration route were found to affect pulmonary dosing efficiency. The authors demonstrate that refinements to dosing techniques can enable reductions in the number of animals needed for bacterial and viral pneumonia studies.

Funder

AABB

American Society of Transplantation

HHS | National Institutes of Health

International Anesthesia Research Society

Sandler Foundation

Publisher

American Physiological Society

Subject

Cell Biology,Physiology (medical),Pulmonary and Respiratory Medicine,Physiology

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