Age-associated differences in the human lung extracellular matrix-Reference-Cited by-同舟云学术

Age-associated differences in the human lung extracellular matrix

Published:2023-06-01 Issue:6 Volume:324 Page:L799-L814
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Koloko Ngassie Maunick Lefin¹²^ORCID,De Vries Maaike²³,Borghuis Theo¹,Timens Wim¹²^ORCID,Sin Don D.⁴^ORCID,Nickle David⁵,Joubert Philippe⁶,Horvatovich Peter⁷^ORCID,Marko-Varga György⁸,Teske Jacob J.⁹^ORCID,Vonk Judith M.²³^ORCID,Gosens Reinoud²¹⁰^ORCID,Prakash Y. S.⁹^ORCID,Burgess Janette K.¹²^ORCID,Brandsma Corry-Anke¹²^ORCID

Affiliation:

1. Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands

2. Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, Netherlands

3. Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands

4. Centre for Heart Lung Innovation at St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada

5. Monoceros Bio, San Diego, California, United States

6. Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec City, Quebec, Canada

7. Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands

8. Center of Excellence in Biological and Medical Mass Spectrometry, Biomedical Center, Lund University, Lund, Sweden

9. Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States

10. Department of Molecular Pharmacology, University of Groningen, Groningen, Netherlands

Abstract

We identified seven age-associated extracellular matrix (ECM) proteins, i.e., COL1A1, COL6A1, COL6A2 COL14A1, FBLN2, LTBP4, and LUM with higher transcript and protein levels in human lung tissue with age. Extensive immunohistochemical analysis revealed significant age-associated differences for COL6A2 in whole tissue, parenchyma, airway wall, and vessel, for COL14A1 and LUM in bronchial epithelium, and COL1A1 in parenchyma. Our findings lay a new foundation for the investigation of ECM differences in age-associated chronic lung diseases.

Funder

University of Groningen and European Union

Healthy Aging Alliance, University Medical Center Groningen, Mayo Clinic

HHS | NIH | National Heart, Lung, and Blood Institute

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Stichting De Cock-Hadders

Publisher

American Physiological Society

Subject

Cell Biology,Physiology (medical),Pulmonary and Respiratory Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00334.2022