Functional roles of CD26/DPP4 in lipopolysaccharide-induced lung injury-Reference-Cited by-同舟云学术

Functional roles of CD26/DPP4 in lipopolysaccharide-induced lung injury

Published:2024-05-01 Issue:5 Volume:326 Page:L562-L573
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Sato Shun¹²,Kawasaki Takeshi¹^ORCID,Hatano Ryo³,Koyanagi Yu¹,Takahashi Yukiko¹,Ohnuma Kei³,Morimoto Chikao³,Dudek Steven M.⁴^ORCID,Tatsumi Koichiro¹,Suzuki Takuji¹²

Affiliation:

1. Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan

2. Synergy Institute for Futuristic Mucosal Vaccine Research and Development, Chiba University, Chiba, Japan

3. Department of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University, Tokyo, Japan

4. Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States

Abstract

We aimed to clarify the functional roles of CD26/DPP4 in ARDS pathophysiology using Dpp4-deficient mice and siRNA reduction techniques in cultured lung cells. Our results suggest that CD26/DPP4 expression plays a proinflammatory role in alveolar macrophages while also playing a protective role in the endothelial barrier. Dpp4 genetic deficiency attenuates inflammatory responses but not permeability in LPS-induced lung injury in mice, potentially through differential roles of CD26/DPP4 expression in the resident cellular components of the lung.

Funder

AMED-CREST

Chiba University

GSK | GlaxoSmithKline Japan

Japan Agency for Medical Research and Development

MEXT | JST | Core Research for Evolutional Science and Technology

MEXT | Japan Society for the Promotion of Science

Ministry of Health, Labour and Welfare

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00392.2022

Reference28 articles.

1. The acute respiratory distress syndrome

2. Acute Respiratory Distress Syndrome

3. The structure and function of CD26 in the T-cell immune response

4. Pharmacology, Physiology, and Mechanisms of Action of Dipeptidyl Peptidase-4 Inhibitors

5. Revisiting an old acquaintance: CD26 and its molecular mechanisms in T cell function