Transplantation of alveolar macrophages improves the efficacy of endothelial progenitor cell therapy in mouse model of bronchopulmonary dysplasia-Reference-Cited by-同舟云学术

Transplantation of alveolar macrophages improves the efficacy of endothelial progenitor cell therapy in mouse model of bronchopulmonary dysplasia

Published:2024-07-01 Issue:1 Volume:327 Page:L114-L125
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Mohammed Afzaal Nadeem¹,Kohram Fatemeh¹,Lan Ying-Wei¹,Li Enhong¹,Kolesnichenko Olena A.²,Kalin Tanya V.¹,Kalinichenko Vladimir V.¹³^ORCID

Affiliation:

1. Department of Child Health, Phoenix Children’s Research Institute, University of Arizona College of Medicine-Phoenix, Phoenix, Arizona, United States

2. Division of Neonatology and Pulmonary Biology, Cincinnati Children’s Research Foundation, Cincinnati, Ohio, United States

3. Division of Neonatology, Phoenix Children’s Hospital, Phoenix, Arizona, United States

Abstract

Recent studies demonstrated that transplantation of lung-resident endothelial progenitor cells (EPC) is an effective therapy in mouse model of bronchopulmonary dysplasia (BPD). However, key factors regulating the efficacy of EPC are unknown. Herein, we demonstrate that transplantation of tissue-resident alveolar macrophages (rAM) increases CXCL12 expression in neonatal mouse lungs. rAM are required for retention of donor EPC in hyperoxia-injured lungs. Co-transplantation of rAM and EPC improves the efficacy of EPC therapy in mouse BPD model.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00274.2023

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