Defining signals that promote human alveolar type I differentiation-Reference-Cited by-同舟云学术

Defining signals that promote human alveolar type I differentiation

Published:2024-04-01 Issue:4 Volume:326 Page:L409-L418
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Li Yong¹,Prakash Y. S.¹²^ORCID,Tan Qi³^ORCID,Tschumperlin Daniel¹^ORCID

Affiliation:

1. Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States

2. Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States

3. The Hormel Institute, University of Minnesota, Austin, Minnesota, United States

Abstract

Alveolar type I (ATI) epithelial cells perform essential roles in maintaining lung function but have been challenging to study. We explored the signals that promote ATI fate in 3-D organoid cultures generated from either mixed distal human lung cells or purified alveolar type II (ATII) cells. This work fills an important void in our experimental repertoire for studying alveolar epithelial cells and identifies signals that promote human ATII to ATI cell differentiation.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Mayo Clinic

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00191.2023

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