Endothelial knockdown of the tumor suppressor, <i>WWOX</i>, increases inflammation in ventilator-induced lung injury-Reference-Cited by-同舟云学术

Endothelial knockdown of the tumor suppressor, WWOX, increases inflammation in ventilator-induced lung injury

Published:2024-06-01 Issue:6 Volume:326 Page:L687-L697
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Zeng Zhenguo¹^ORCID,Abdelwahid Eltyeb²,Chen Weiguo²^ORCID,Ascoli Christian²^ORCID,Pham Trinh²,Jacobson Jeffrey R.²^ORCID,Dudek Steven M.²^ORCID,Natarajan Viswanathan²,Aldaz C. Marcelo³,Machado Roberto F.⁴^ORCID,Singla Sunit²^ORCID

Affiliation:

1. Department of Critical Care Medicine, Medical Center of Anesthesiology and Pain, the First Affiliation Hospital, Jiangxi Medical College, Nanchang University, Nanchang, People’s Republic of China

2. Division of Pulmonary, Critical Care, Sleep and Allergy Medicine, University of Illinois at Chicago, Chicago, Illinois, United States

3. MD Anderson Cancer Center, University of Texas, Houston, Texas, United States

4. Division of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Indiana University, Indianapolis, Indiana, United States

Abstract

Prior tobacco smoke exposure is associated with an increased risk of acute respiratory distress syndrome (ARDS) during critical illness. Our laboratory is investigating one of the gene expression changes that occurs in the lung following smoke exposure: WWOX downregulation. Here we describe changes in protein expression associated with WWOX knockdown and its influence on ventilator-induced ARDS in a mouse model.

Funder

江西省科学技术厅 | Natural Science Foundation of Jiangxi Province

HHS | National Institutes of Health

MOST | National Natural Science Foundation of China

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00277.2023

Reference33 articles.

1. Molecular Functions of WWOX Potentially Involved in Cancer Development

2. WWOX, the FRA16D gene: A target of and a contributor to genomic instability

3. Cigarette Smoke and Nicotine-Containing Electronic-Cigarette Vapor Downregulate Lung WWOX Expression, Which Is Associated with Increased Severity of Murine Acute Respiratory Distress Syndrome

4. Loss of lung WWOX expression causes neutrophilic inflammation

5. Acute Respiratory Distress Syndrome