Fatty acid metabolism promotes TRPV4 activity in lung microvascular endothelial cells in pulmonary arterial hypertension-Reference-Cited by-同舟云学术

Fatty acid metabolism promotes TRPV4 activity in lung microvascular endothelial cells in pulmonary arterial hypertension

Published:2024-03-01 Issue:3 Volume:326 Page:L252-L265
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Philip Nicolas¹,Yun Xin¹,Pi Hongyang²,Murray Samuel¹,Hill Zack¹,Fonticella Jay¹^ORCID,Perez Preston¹,Zhang Cissy³,Pathmasiri Wimal⁴,Sumner Susan⁴,Servinsky Laura¹^ORCID,Jiang Haiyang¹,Huetsch John C.¹,Oldham William M.⁵^ORCID,Visovatti Scott⁶,Leary Peter J.²,Gharib Sina A.²^ORCID,Brittain Evan⁷,Simpson Catherine E.¹^ORCID,Le Anne³,Shimoda Larissa A.¹^ORCID,Suresh Karthik¹^ORCID

Affiliation:

1. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

2. Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States

3. Gigantest, Inc., Baltimore, Maryland, United States

4. Department of Nutrition, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina, United States

5. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States

6. Department of Cardiology, Ohio State University School of Medicine, Columbus, Ohio, United States

7. Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States

Abstract

In this paper, we explore the link between metabolism and intracellular calcium levels in microvascular endothelial cells (MVECs) in pulmonary arterial hypertension (PAH). We show that fatty acid oxidation promotes sensitivity of the transient receptor potential vanilloid-4 (TRPV4) calcium channel in MVECs isolated from a rodent model of PAH.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | National Institutes of Health

JHU | School of Medicine, Johns Hopkins University

JHHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00199.2023

Reference26 articles.

1. Reactive oxygen species induced Ca2+ influx via TRPV4 and microvascular endothelial dysfunction in the SU5416/hypoxia model of pulmonary arterial hypertension

2. Regulation of mitochondrial fragmentation in microvascular endothelial cells isolated from the SU5416/hypoxia model of pulmonary arterial hypertension

3. Human PAH is characterized by a pattern of lipid-related insulin resistance

4. Fatty Acid Metabolism in Pulmonary Arterial Hypertension: Role in Right Ventricular Dysfunction and Hypertrophy

5. clusterProfiler 4.0: A universal enrichment tool for interpreting omics data

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