Exhaled breath condensate identifies metabolic dysregulation in patients with radiation-induced lung injury-Reference-Cited by-同舟云学术

Exhaled breath condensate identifies metabolic dysregulation in patients with radiation-induced lung injury

Published:2023-06-01 Issue:6 Volume:324 Page:L863-L869
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Pierre-Louis Odoom Josly¹²,Freeberg Margaret A. T.¹^ORCID,Camus Sarah V.¹,Toft Robin¹,Szomju Barbara B.¹,Sanchez Rosado Rose Marie¹^ORCID,Jackson Peter D.¹,Allegood Jeremy C.³,Silvey Scott⁴^ORCID,Liu Jinze⁴,Cowart L. Ashley³⁵,Weiss Elisabeth⁶^ORCID,Thatcher Thomas H.¹^ORCID,Sime Patricia J.¹^ORCID

Affiliation:

1. Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, United States

2. Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia, United States

3. Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia, United States

4. Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia, United States

5. Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, Virginia, United States

6. Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia, United States

Abstract

We report that exhaled breath condensate (EBC) identifies cellular metabolic dysregulation in patients with radiation-induced lung injury. In this pilot study, untargeted metabolomics revealed a striking metabolic signature in EBC from patients with radiation-induced lung fibrosis compared to patients with lung cancer, at-risk smokers, and healthy volunteers. Patients with radiation-induced fibrosis exhibit specific changes in tricarboxylic acid (TCA) cycle energy metabolism that may be required to support the increased energy demands of fibroproliferation.

Funder

Chandler-Pollock-Solimano-Thomas Pulmonary Fibrosis Research Fund

Ford Foundation

HHS | NIH | National Cancer Institute

HHS | NIH | National Heart, Lung, and Blood Institute

Pulmonary Fibrosis Foundation

Publisher

American Physiological Society

Subject

Cell Biology,Physiology (medical),Pulmonary and Respiratory Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00439.2022