Endoplasmic reticulum stress enhances the expression of TLR3-induced TSLP by airway epithelium-Reference-Cited by-同舟云学术

Endoplasmic reticulum stress enhances the expression of TLR3-induced TSLP by airway epithelium

Published:2024-05-01 Issue:5 Volume:326 Page:L618-L626
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Pathinayake Prabuddha S.¹^ORCID,Hsu Alan C.-Y.¹²^ORCID,Nichol Kristy S.¹,Horvat Jay C.³,Hansbro Philip M.³⁴^ORCID,Wark Peter A. B.¹⁵⁶⁷^ORCID

Affiliation:

1. Immune Health Program, Hunter Medical Research Institute and School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia

2. Signature Research Program in Emerging Infectious Diseases, Duke-National University of Singapore (NUS) Graduate Medical School, Singapore, Singapore

3. Immune Health Program, Hunter Medical Research Institute and School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia

4. Faculty of Science, School of Life Sciences, Centre for Inflammation, Centenary Institute, University of Technology Sydney, Sydney, New South Wales, Australia

5. Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, New South Wales, Australia

6. School of Medicine, Monash University, Melbourne, Victoria, Australia

7. AIRMED Alfred Health, Melbourne, Victoria, Australia

Abstract

TSLP is an epithelial-derived cytokine and a key regulator in the pathogenesis of severe uncontrolled asthma. We demonstrate a novel mechanism by which endoplasmic reticulum stress signaling upregulates airway epithelial TSLP mRNA expression via the PERK-CHOP signaling pathway and enhances TLR3-mediated TSLP protein secretion.

Funder

DHAC | National Health and Medical Research Council

University of Technology Sydney

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00378.2023

Reference41 articles.

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5. Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP