Lack of a transcriptional response of primary bronchial epithelial cells from patients with asthma and controls to IL-33-Reference-Cited by-同舟云学术

Lack of a transcriptional response of primary bronchial epithelial cells from patients with asthma and controls to IL-33

Published:2024-01-01 Issue:1 Volume:326 Page:L65-L70
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Saikumar Jayalatha Akshaya Keerthi¹^ORCID,Jonker Marnix R.¹^ORCID,Carpaij Orestes A.²,van den Berge Maarten²^ORCID,Affleck Karen X.³,Koppelman Gerard H.⁴^ORCID,Nawijn Martijn C.¹^ORCID

Affiliation:

1. Laboratory of Experimental Pulmonology and Inflammation Research (EXPIRE), Department of Pathology and Medical Biology, GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

2. Department of Pulmonary Diseases, GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

3. Immunology Research Unit, GlaxoSmithkline, Stevenage, United Kingdom

4. Department of Pediatric Pulmonology and Pediatric Allergology, GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Abstract

The IL-33/IL-1RL1 pathway stands as a formidable genetic predisposition for asthma, with ongoing clinical developments of various drugs designed to mitigate its influence in patients with asthma. The absence of a transcriptomic reaction to IL-33 within the bronchial epithelium holds significance in the pursuit of identifying biomarkers that can aid in pinpointing those individuals who would derive the greatest benefit from therapies targeting the IL-33 pathway.

Funder

GlaxoSmithKline

Longfonds

Lung Foundation Netherlands

Publisher

American Physiological Society

Subject

Cell Biology,Physiology (medical),Pulmonary and Respiratory Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00298.2023

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5. A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma