Liraglutide pretreatment attenuates sepsis-induced acute lung injury-Reference-Cited by-同舟云学术

Liraglutide pretreatment attenuates sepsis-induced acute lung injury

Published:2023-09-01 Issue:3 Volume:325 Page:L368-L384
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Baer Brandon¹^ORCID,Putz Nathan D.¹²,Riedmann Kyle²,Gonski Samantha¹,Lin Jason¹,Ware Lorraine B.¹²^ORCID,Toki Shinji¹,Peebles R. Stokes¹²³⁴,Cahill Katherine N.¹^ORCID,Bastarache Julie A.¹²³^ORCID

Affiliation:

1. Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States

2. Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States

3. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States

4. United States Department of Veterans Affairs, Nashville, Tennessee, United States

Abstract

In this study, pretreatment with liraglutide, a commonly used diabetes medication and glucagon-like peptide-1 (GLP-1) receptor agonist, attenuated sepsis-induced acute lung injury in a two-hit mouse model (sepsis + hyperoxia). Septic mice who received the drug were less sick, lived longer, and displayed reduced lung inflammation, edema, and injury. These therapeutic effects were not dependent on weight loss. GLP-1 receptor activation may hold promise as a new treatment strategy for sepsis-induced acute respiratory distress syndrome.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Physiological Society

Subject

Cell Biology,Physiology (medical),Pulmonary and Respiratory Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00041.2023

Reference119 articles.

1. Pharmacotherapy for Prevention and Treatment of Acute Respiratory Distress Syndrome

2. Sepsis and Acute Respiratory Distress Syndrome: Recent Update

3. Acute Respiratory Distress Syndrome

4. A Review of Acute Respiratory Distress Syndrome Management and Treatment

5. Clinical trials in acute respiratory distress syndrome: challenges and opportunities

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