Notch signaling inactivation by small molecule γ-secretase inhibitors restores the multiciliated cell population in the airway epithelium-Reference-Cited by-同舟云学术

Notch signaling inactivation by small molecule γ-secretase inhibitors restores the multiciliated cell population in the airway epithelium

Published:2023-06-01 Issue:6 Volume:324 Page:L771-L782
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Vladar Eszter K.¹²^ORCID,Kunimoto Koshi²,Rojas-Hernandez Laura S.³^ORCID,Spano Jacquelyn M.³,Sellers Zachary M.⁴^ORCID,Joo Nam Soo³,Cooney Riley A.¹^ORCID,Axelrod Jeffrey D.²^ORCID,Milla Carlos E.³^ORCID

Affiliation:

1. Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States

2. Department of Pathology, Stanford University School of Medicine, Stanford, California, United States

3. Center for Excellence in Pulmonary Biology, Stanford University School of Medicine, Stanford, California, United States

4. Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States

Abstract

Our findings show that low-dose, short-term topical or systemic γ-secretase inhibitor treatment may lead to restoration of multiciliated cells without toxicity and potentially improve epithelial function in a wide range of chronic lung diseases.

Funder

A.P. Giannini Foundation

School of Medicine, Stanford University

Cystic Fibrosis Foundation

SU | SOM | Stanford Maternal and Child Health Research Institute

Publisher

American Physiological Society

Subject

Cell Biology,Physiology (medical),Pulmonary and Respiratory Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00382.2022

Reference45 articles.