Loss of growth differentiation factor 15 exacerbates lung injury in neonatal mice-Reference-Cited by-同舟云学术

Loss of growth differentiation factor 15 exacerbates lung injury in neonatal mice

Published:2023-09-01 Issue:3 Volume:325 Page:L314-L326
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Al-Mudares Faeq¹,Cantu Gutierrez Manuel²^ORCID,Cantu Abiud²^ORCID,Jiang Weiwu¹,Wang Lihua¹,Dong Xiaoyu¹,Moorthy Bhagavatula¹,Sajti Eniko³^ORCID,Lingappan Krithika²^ORCID

Affiliation:

1. Section of Neonatology, Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, Houston, Texas, United States

2. Divsion of Neonatology, Department of Pediatrics, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, United States

3. Division of Neonatology, Department of Pediatrics, University of California, San Diego, California, United States

Abstract

We show for the first time that loss of Gdf15 exacerbates mortality, lung injury, and the phenotype of the arrest of alveolarization in the developing lung with loss of female-sex advantage in Gdf15−/− mice. We also highlight the distinct pulmonary transcriptomic response in the Gdf15−/− lung including pathways related to macrophage recruitment and activation.

Funder

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

HHS | NIH | NHLBI | NHLBI Division of Intramural Research

HHS | NIH | National Institute of Environmental Health Sciences

Publisher

American Physiological Society

Subject

Cell Biology,Physiology (medical),Pulmonary and Respiratory Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00086.2023

Reference85 articles.

1. Assessment of an Updated Neonatal Research Network Extremely Preterm Birth Outcome Model in the Vermont Oxford Network