Endothelial-specific loss of IKKβ disrupts pulmonary endothelial angiogenesis and impairs postnatal lung growth-Reference-Cited by-同舟云学术

Endothelial-specific loss of IKKβ disrupts pulmonary endothelial angiogenesis and impairs postnatal lung growth

Published:2023-09-01 Issue:3 Volume:325 Page:L299-L313
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Rao Shailaja¹²,Liu Min¹²,Iosef Cristiana¹²,Knutsen Carsten¹²,Alvira Cristina M.¹²^ORCID

Affiliation:

1. Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California, United States

2. Stanford Center for Excellence in Pulmonary Biology, Palo Alto, California, United States

Abstract

This study highlights the cell-specific complexity of nuclear factor kappa B signaling in the developing lung by demonstrating that inducible loss of IKKβ in endothelial cells impairs alveolarization, disrupts EC angiogenic function, and broadly represses genes important for vascular development.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Stanford University

Publisher

American Physiological Society

Subject

Cell Biology,Physiology (medical),Pulmonary and Respiratory Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00034.2023

Reference72 articles.

1. Structural Aspects of Postnatal Lung Development – Alveolar Formation and Growth

2. Disrupted Pulmonary Vasculature and Decreased Vascular Endothelial Growth Factor, Flt-1, and TIE-2 in Human Infants Dying with Bronchopulmonary Dysplasia

3. Vascular Endothelial Growth Factor Gene Therapy Increases Survival, Promotes Lung Angiogenesis, and Prevents Alveolar Damage in Hyperoxia-Induced Lung Injury

4. Inhibition of angiogenesis decreases alveolarization in the developing rat lung

5. Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure

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