The alveolar fibroproliferative response in moderate to severe COVID-19-related acute respiratory distress syndrome and 1-yr follow-up-Reference-Cited by-同舟云学术

The alveolar fibroproliferative response in moderate to severe COVID-19-related acute respiratory distress syndrome and 1-yr follow-up

Published:2024-01-01 Issue:1 Volume:326 Page:L7-L18
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Zhang Shiqi¹^ORCID,Boers Leonoor S.¹^ORCID,de Brabander Justin²,van den Heuvel Laura B.¹,Blok Siebe G.¹,Kullberg Robert F. J.²,Smids-Dierdorp Barbara S.³⁴,Dekker Tamara³⁴,Aberson Hella L.⁴,Meijboom Lilian J.⁵,Vlaar Alexander P. J.¹⁶,Heunks Leo⁷^ORCID,Nossent Esther J.⁸,van der Poll Tom²⁹^ORCID,Bos Lieuwe D. J.¹⁶^ORCID,Duitman JanWillem³⁴¹⁰^ORCID,

Affiliation:

1. Intensive Care Medicine, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands

2. Center for Experimental and Molecular Medicine (CEMM), Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands

3. Pulmonary Medicine, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands

4. Experimental Immunology (EXIM), Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands

5. Radiology and Nuclear Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

6. Laboratory of Experimental Intensive Care and Anesthesiology (LEICA), Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands

7. Intensive Care Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands

8. Pulmonary Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

9. Division of Infectious Diseases, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands

10. Infection & Immunity, Inflammatory Diseases, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands

Abstract

This is the first prospective study on the longitudinal alveolar fibroproliferative response in COVID-19 ARDS and its relationship with mortality and long-term follow-up. We used the largest cohort of COVID-19 ARDS patients who had consecutive bronchoalveolar lavages and measured 17 pulmonary fibroproliferative biomarkers. We found that a higher fibroproliferative response during admission was associated with increased mortality, but not correlated with long-term fibrotic lung sequelae in survivors.

Funder

Amsterdam University Medical Centers

China Scholarship Council

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

American Physiological Society

Subject

Cell Biology,Physiology (medical),Pulmonary and Respiratory Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00156.2023

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