Complex urban atmosphere alters alveolar stem cells niche properties and drives lung fibrosis-Reference-Cited by-同舟云学术

Complex urban atmosphere alters alveolar stem cells niche properties and drives lung fibrosis

Published:2023-10-01 Issue:4 Volume:325 Page:L447-L459
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Belgacemi Randa¹²^ORCID,Ribeiro Baptista Bruno¹,Justeau Grégoire¹,Toigo Marylène¹,Frauenpreis Andrew²,Yilmaz Rojda¹,Der Vartanian Audrey¹^ORCID,Cazaunau Mathieu³,Pangui Edouard³,Bergé Antonin⁴,Gratien Aline⁴,Macias Rodriguez Juan Camilo⁴,Bellusci Saverio⁵,Derumeaux Geneviève¹⁶^ORCID,Boczkowski Jorge¹,Al Alam Denise²^ORCID,Coll Patrice⁴,Lanone Sophie¹,Boyer Laurent¹⁶^ORCID

Affiliation:

1. Université Paris Est Créteil, INSERM, IMRB, FHU Senec, Créteil, France

2. Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, California, United States

3. Université Paris Est Créteil and Université Paris Cité, CNRS, LISA, Créteil, France

4. Université Paris Cité and Université Paris Est Créteil, CNRS, LISA, Paris, France

5. German Center for Lung Research (DZL), Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Justus Liebig University Giessen, Giessen, Germany

6. Service de Physiologie-Explorations Fonctionnelles, Hôpital Henri Mondor, Créteil, France

Abstract

Urban pollution is known to have major adverse effects on lung health. To assess the effect of pollution on alveolar regeneration, we exposed adult mice to a simulated high-pollution urban atmosphere, using an innovative CESAM simulation chamber (Multiphase Atmospheric Experimental Simulation Chamber, https://cesam.cnrs.fr/ ). We demonstrated that urban atmosphere alters alveolar mesenchymal stem cell niche properties by inducing a lipofibroblast to myofibroblast shift and induces alveolar epithelial dysfunction.

Funder

Agence Nationale de Sécurité Sanitaire de l'Alimentation, de l'Environnement et du Travail

California Institute for Regenerative Medicine

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Cell Biology,Physiology (medical),Pulmonary and Respiratory Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00061.2023

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