Diurnal properties of tonic and synaptic GABAA receptor-mediated currents in suprachiasmatic nucleus neurons-Reference-Cited by-同舟云学术

Diurnal properties of tonic and synaptic GABAA receptor-mediated currents in suprachiasmatic nucleus neurons

Published:2021-08-01 Issue:2 Volume:126 Page:637-652
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Moldavan Michael¹^ORCID,Cravetchi Olga¹,Allen Charles N.¹²^ORCID

Affiliation:

1. Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, Oregon

2. Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon

Abstract

A tonic current ( Itonic) mediated by GABAA receptors (GABAARs) containing α4-, α5- and δ-subunits was observed in the suprachiasmatic nucleus. The Itonic amplitude strongly depended on the action potential-mediated synaptic release of GABA. The equilibrium potential for Itonic corresponds to that for GABAA currents. The frequency of GABAA postsynaptic currents and Itonic amplitude increased during the day, with peak in the middle of the day, and then gradually declined with a nadir at night, thus showing a diurnal rhythm.

Funder

HHS | NIH | National Institute of Neurological Disorders and Stroke

HHS | NIH | National Center for Research Resources

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00556.2020

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