Daily acute intermittent hypoxia enhances phrenic motor output and stimulus-evoked phrenic responses in rats

Author:

Perim Raphael R.1,Sunshine Michael D.1ORCID,Welch Joseph F.1,Santiago Juliet1ORCID,Holland Ashley1,Ross Ashley1,Mitchell Gordon S.1,Gonzalez-Rothi Elisa J.1ORCID

Affiliation:

1. Breathing Research and Therapeutics Center, Department of Physical Therapy and McKnight Brain Institute, University of Florida, Gainesville, Florida

Abstract

Two weeks of daily acute intermittent hypoxia (dAIH) preconditioning enhanced stimulus-evoked phrenic responses to lateral funiculus stimulation (targeting respiratory bulbospinal projection to phrenic motor neurons). Furthermore, dAIH preconditioning enhanced baseline phrenic motor output responses to maximal chemoreflex activation in intact rats.

Funder

Craig H. Neilsen Foundation

Eunice Kennedy Shriver National Institute of Child Health and Human Development

McKnight Brain Institute, University of Florida

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

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