Modulation of exteroceptive electromyographic responses in defensive peripersonal space

Abstract

The cutaneous silent period (CSP) to noxious finger stimulation constitutes a robust spinal inhibitory reflex that protects the hand from injury. In certain conditions, spinal inhibition is interrupted by a brief burst-like electromyographic activity, dividing the CSP into two inhibitory phases (I1 and I2). This excitatory component is termed long-loop reflex (LLR) and is presumed to be transcortical in origin. Efficient defense from environmental threats requires sensorimotor integration between multimodal sensory afferents and planning of defensive movements. In the defensive peripersonal space (DPPS) immediately surrounding the body, we interact with objects and persons with increased alertness. We investigated whether CSP differs when the stimulated hand is in the DPPS of the face compared with a distant position. Furthermore, we investigated the possible role of vision in CSP modulation. Fifteen healthy volunteers underwent CSP testing with the handheld either within 5 cm from the nose (near) or away from the body (far). Recordings were obtained from first dorsal interosseous muscle following index (D2) or little finger (D5) stimulation with varying intensities. A subgroup of subjects underwent CSP recordings in near and far conditions, both with eyes open and with eyes closed. No inhibitory CSP parameter differed between stimulation in near and far conditions. LLRs occurring following D2 stimulation were significantly larger in near than far conditions at all stimulus intensities, irrespective of subjects seeing their hand. Similar to the hand-blink reflex, spinally organized protective reflexes may be modulated by corticospinal facilitatory input when the hand enters the DPPS of the face. NEW & NOTEWORTHY The present findings demonstrate for the first time that a spinally organized protective reflex, the cutaneous silent period (CSP), may be modulated by top-down corticospinal facilitatory input when the stimulated hand enters the defensive peripersonal space (DPPS) of the face. In particular, the cortically mediated excitatory long-loop reflex, which may interrupt the CSP, is facilitated when the stimulated hand is in the DPPS, irrespective of visual control over the hand. No spinal inhibitory CSP parameter differs significantly in or outside the DPPS.