Dexmedetomidine mitigates neuroinflammation and improves early postoperative neurocognitive dysfunction in rats by enhancing autophagy-Reference-Cited by-同舟云学术

Dexmedetomidine mitigates neuroinflammation and improves early postoperative neurocognitive dysfunction in rats by enhancing autophagy

Published:2023-05-01 Issue:5 Volume:129 Page:1145-1156
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Wang Jinxu¹^ORCID,Xin Yueyang¹,Chu Tiantian¹^ORCID,Zhou Yaqun¹,Liu Cheng¹,Xu Aijun¹^ORCID

Affiliation:

1. Department of Anesthesiology, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China

Abstract

Dex inhibits hippocampal neuroinflammation and attenuates early cognitive impairment by enhancing autophagy following surgery in rats. Dex may protect postoperative cognitive function by activating the LKB1/AMPK/ULK-1 signaling pathway.

Funder

Natural Science Foundation of Hubei Province

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00019.2023

Reference70 articles.

1. Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study

2. Surgery, neuroinflammation and cognitive impairment

3. Predictors of Cognitive Dysfunction after Major Noncardiac Surgery

4. Dexmedetomidine Attenuates Lung Injury in Toxic Shock Rats by Inhibiting Inflammation and Autophagy

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