Acute changes in nerve excitability following oxaliplatin treatment in mice-Reference-Cited by-同舟云学术

Acute changes in nerve excitability following oxaliplatin treatment in mice

Published:2020-07-01 Issue:1 Volume:124 Page:232-244
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Makker Preet G. S.¹,White Daniel¹^ORCID,Lees Justin G.¹,Parmar Jasneet¹,Goldstein David²³,Park Susanna B.⁴,Howells James⁵^ORCID,Moalem-Taylor Gila¹^ORCID

Affiliation:

1. Translational Neuroscience Facility, School of Medical Sciences, University of New South Wales (UNSW), Sydney, New South Wales, Australia

2. Department of Medical Oncology, Prince of Wales Hospital, Randwick, New South Wales, Australia

3. Prince of Wales Clinical School, UNSW, New South Wales, Australia

4. Brain and Mind Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia

5. Central Clinical School, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia

Abstract

We present a novel mouse model of acute oxaliplatin-induced peripheral neurotoxicity that is comparable to clinical observations. Intramuscular injection of oxaliplatin produced acute changes in motor nerve excitability that were attributable to alterations in Na+ and K+ channel activity. Conversely, we were unable to show any significant changes in nerve excitability with systemic intraperitoneal injections of oxaliplatin. This study suggests that local intramuscular injection is a valid approach for modelling oxaliplatin-induced peripheral neuropathy in animals.

Funder

Cancer Institute NSW Translational Program Grant

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00260.2020

Reference42 articles.

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2. Topiramate prevents oxaliplatin-related axonal hyperexcitability and oxaliplatin induced peripheral neurotoxicity.

3. Clinical pattern and associations of oxaliplatin acute neurotoxicity