The ubiquitin E3 ligase Parkin regulates neuronal Ca<sub>V</sub>1.3 channel functional expression-Reference-Cited by-同舟云学术

The ubiquitin E3 ligase Parkin regulates neuronal Ca_V1.3 channel functional expression

Published:2022-12-01 Issue:6 Volume:128 Page:1555-1564
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Grimaldo Lizbeth¹^ORCID,Sandoval Alejandro²,Duran Paz³^ORCID,Gómez Flores-Ramos Liliana¹^ORCID,Felix Ricardo⁴^ORCID

Affiliation:

1. Conacyt, Population Health Research Center, National Institute of Public Health, Cuernavaca, Mexico

2. School of Medicine FES Iztacala, National Autonomous University of Mexico (UNAM), Tlalnepantla, Mexico

3. Department of Molecular Pathobiology, College of Dentistry, New York University, New York, New York

4. Department of Cell Biology, Centre for Research and Advanced Studies of the National Polytechnic Institute (Cinvestav-IPN), Mexico City, Mexico

Abstract

The increased expression of CaV1.3 calcium channels is a crucial feature of Parkinson’s disease (PD) pathophysiology. However, the mechanisms that determine this increase are not yet defined. Parkin, an enzyme of the ubiquitin-proteasome system, is known to interact with neuronal channels promoting their ubiquitin-mediated degradation. Interestingly, Parkin mutations also play a role in PD. Here, the degradation mechanisms of CaV1.3 channels and their relationship with the pathophysiology of PD are studied in detail.

Funder

Consejo Nacional de Ciencia y Tecnología

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00287.2022

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