Changes of cortical gray matter volume during development: a Human Connectome Project study

Abstract

We report mixed effects of age on cortical gray matter volume during development in a large sample of 649 participants studied in an identical manner (6–21 yr old, 299 males, 350 females). Volumes of 30/35 cortical areas decreased with age, temporal pole increased, and pericalcarine and hippocampal cortex (hippocampus, parahippocampal, and entorhinal) did not change. These findings were very similar in both sexes and provide a solid base for assessing region-specific cortical changes during development.