Structural covariation between cerebellum and neocortex intrinsic structural covariation links cerebellum subregions to the cerebral cortex-Reference-Cited by-同舟云学术

Structural covariation between cerebellum and neocortex intrinsic structural covariation links cerebellum subregions to the cerebral cortex

Published:2024-09-01 Issue:3 Volume:132 Page:849-869
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Wang Zilong¹²^ORCID,Diedrichsen Jörn³⁴⁵^ORCID,Saltoun Karin¹²^ORCID,Steele Christopher⁶⁷,Arnold-Anteraper Sheeba Rani⁸⁹,Yeo B. T. Thomas¹⁰,Schmahmann Jeremy D.¹¹,Bzdok Danilo¹²

Affiliation:

1. McConnell Brain Imaging Centre, Department of Biomedical Engineering, Faculty of Medicine, School of Computer Science, The Neuro—Montreal Neurological Institute (MNI), McGill University, Montreal, Quebec, Canada

2. Mila—Quebec Artificial Intelligence Institute, Montreal, Quebec, Canada

3. Western Institute for Neuroscience, Western University, London, Ontario, Canada

4. Department of Computer Science, Western University, London, Ontario, Canada

5. Department of Statistical and Actuarial Sciences, Western University, London, Ontario, Canada

6. Department of Psychology, Concordia University, Montreal, Quebec, Canada

7. Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

8. Advanced Imaging Research Center, UTSW, Dallas, Texas, United States

9. Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, Illinois, United States

10. Department of Electrical & Computer Engineering, Centre for Translational MR Research, Centre for Sleep & Cognition, N.1 Institute for Health and Institute for Digital Medicine, National University of Singapore, Singapore, Singapore

11. Ataxia Center, Cognitive Behavioral Neurology Unit, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States

Abstract

Cerebellum’s association with the entire cerebral cortex has not been holistically studied in a unified way. Here, we conjointly characterize the population-level cortical-cerebellar structural covariation patterns leveraging ∼40,000 UK Biobank participants whole brain structural scans and ∼1,000 phenotypes. We revitalize the previous hypothesis of an anticorrelation between the visual-attention system and advanced associative networks within the cerebellum. We also discovered a novel ipsilateral cerebral-cerebellar associations. Phenome-wide association (PheWAS) revealed real-world implications of the structural covariation patterns.

Funder

NUS Yong Loo Lin School of Medicine

HHS | National Institutes of Health

MOH | National Medical Research Council

Temasek Foundation

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00164.2024

Reference201 articles.

1. An Emerging Concept

2. Anatomical investigation of projections to the basis pontis from posterior parietal association cortices in rhesus monkey

3. Projections to the basis pontis from the superior temporal sulcus and superior temporal region in the rhesus monkey

4. Anatomic Organization of the Basilar Pontine Projections from Prefrontal Cortices in Rhesus Monkey