Does a single oral administration of amiloride affect spontaneous arterial baroreflex sensitivity and blood pressure variability in healthy young adults?-Reference-Cited by-同舟云学术

Does a single oral administration of amiloride affect spontaneous arterial baroreflex sensitivity and blood pressure variability in healthy young adults?

Published:2024-09-01 Issue:3 Volume:132 Page:922-928
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Fernandes Igor A.¹^ORCID,Stavres Jon²³^ORCID,Hamaoka Takuto²^ORCID,Ojikutu Qudus A.¹^ORCID,Sabino-Carvalho Jeann L.⁴^ORCID,Vianna Lauro C.⁵^ORCID,Luck J. Carter²^ORCID,Blaha Cheryl²,Cauffman Aimee E.²,Dalton Paul C.²,Herr Michael D.²,Ruiz-Velasco Victor⁶^ORCID,Carr Zyad J.⁷^ORCID,Janicki Piotr K.⁶,Cui Jian²^ORCID

Affiliation:

1. Human Neurovascular Control Laboratory, Department of Health and Kinesiology, Purdue University, West Lafayette, Indiana, United States

2. Penn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States

3. School of Kinesiology and Nutrition, University of Southern Mississippi, Hattiesburg, Mississippi, United States

4. Division of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States

5. NeuroV̇ASQ̇—Integrative Physiology Laboratory, Faculty of Physical Education, University of Brasília, Federal District, Brazil

6. Department of Anesthesiology and Perioperative Medicine, Penn State University College of Medicine, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States

7. Department of Anesthesiology, Yale School of Medicine, Yale New Haven Hospital, New Haven, Connecticut

Abstract

Preclinical models indicate that amiloride (AMD), a nonselective antagonist of the acid-sensing ion channels (ASICs), impairs baroreflex sensitivity and perturbs blood pressure regulation. We translated these findings into humans, investigating the impact of acute oral ingestion of AMD on blood pressure variability and spontaneous cardiac and sympathetic baroreflex sensitivity in healthy young humans. In contrast to preclinical evidence, AMD does not impair spontaneous arterial baroreflex sensitivity and blood pressure variability in healthy young adults.

Funder

HHS | National Institutes of Health

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00264.2024

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