Effects of prenatal ethanol exposure on choline-induced long-term depression in the hippocampus

Author:

Grafe Erin L.1,Fontaine Christine J.1,Thomas Jennifer D.2,Christie Brian R.13ORCID

Affiliation:

1. Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada

2. Department of Psychology, San Diego State University, San Diego, California

3. Island Medical Program, Department of Cellular and Physiological Sciences, University of British Columbia, Victoria, British Columbia, Canada

Abstract

Choline supplementation is a nutraceutical therapy with significant potential for a variety of developmental disorders; however, the mechanisms involved in its therapeutic effects remain poorly understood. Our research shows that choline directly impacts synaptic communication in the brain, inducing a long-term depression of synaptic efficacy in brain slices. The depression is equivalent in male and female animals, involves M1 receptors in control animals, but uniquely involves NMDA receptors in a model of FASD.

Funder

Gouvernement du Canada | CIHR | Institute of Neurosciences, Mental Health and Addiction

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

HHS | NIH | National Institute on Alcohol Abuse and Alcoholism

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

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