Ketamine induced converged synchronous gamma oscillations in the cortico-basal ganglia network of nonhuman primates-Reference-Cited by-同舟云学术

Ketamine induced converged synchronous gamma oscillations in the cortico-basal ganglia network of nonhuman primates

Published:2017-08-01 Issue:2 Volume:118 Page:917-931
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Slovik Maya¹²³,Rosin Boris¹⁴,Moshel Shay¹⁵⁶,Mitelman Rea¹⁵,Schechtman Eitan⁵,Eitan Renana¹⁷,Raz Aeyal⁸⁹,Bergman Hagai¹⁵¹⁰

Affiliation:

1. Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel

2. Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel

3. Department of Family Medicine, Clalit Health Services, Jerusalem, Israel

4. Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

5. The Interdisciplinary Center for Neural Computation and Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, Israel

6. The Research Laboratory of Brain Imaging and Stimulation, The Jerusalem Mental Health Center, Kfar-Shaul Eitanim, Hebrew University-Hadassah Medical School, Jerusalem, Israel

7. Functional Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts

8. Department of Anesthesiology, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin

9. Department of Anesthesiology, Rambam Health Care Campus, Haifa, Israel

10. Department of Neurosurgery, Hadassah Medical Center, Jerusalem, Israel

Abstract

This study is the first to show spontaneous gamma oscillations under NMDA antagonist in nonhuman primates. These oscillations appear in synchrony in the cortex and the basal ganglia. Phase analysis refutes the confounding effects of volume conduction and supports the funneling and amplifying architecture of the cortico-basal ganglia loops. These results suggest an abnormal network phenomenon with a unique spectral signature that could account for pathological mental and neurological states.

Funder

EC | European Research Council (ERC)

Adelis

Rostrees and Vorst foundation

The Simone and Bernard Guttman Chair in Brain Research

International Anesthesia Research Society

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://www.physiology.org/doi/pdf/10.1152/jn.00765.2016