Reciprocal Stimulation of Decay Between Serotonergic Facilitation and Depression of Synaptic Transmission

Author:

Lee Sun Hee Cho,Taylor Karen,Krasne Franklin B.

Abstract

Serotonin can produce multiple, contradictory modulatory effects on strength of synaptic transmission in both vertebrate and invertebrate nerve circuits. In crayfish, serotonin (5-HT) can both facilitate and depress transmission to lateral giant escape command neurons; however, which effect is manifest during application, as well as the sign and duration of effects that may continue long after 5-HT washout, may depend on history of application as well as on concentration. We report that protein kinase A (PKA) signaling is essential to the production of facilitation but depression is mediated by non-cAMP/PKA signaling pathways. However, we unexpectedly found that PKA activity is essential for the decay of depression when serotonin is washed out. This, and evidence from the effects of a variety of serotonin application regimens, suggest that facilitatory and depressive states coexist and compete and that the decay of each is dependent on stimulation by the other. A computational model that incorporates these assumptions can account for and rationalize the varied effects of a wide range of serotonin application regimens.

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Cited by 15 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Identification and Characterization of 5-HT Receptor 1 from Scylla paramamosain: The Essential Roles of 5-HT and Its Receptor Gene during Aggressive Behavior in Crab Species;International Journal of Molecular Sciences;2023-02-20

2. Serotonergic-linked alterations of aggression of the crayfish;Marine and Freshwater Behaviour and Physiology;2020-08-24

3. Serotonin in Animal Cognition and Behavior;International Journal of Molecular Sciences;2020-02-28

4. Serotonergic control of excitability: from neuron to networks;Handbook of Behavioral Neuroscience;2020

5. Duality of 5-HT Effects on Crayfish Motoneurons;Frontiers in Physiology;2019-10-22

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