The stochastic nature of action potential backpropagation in apical tuft dendrites-Reference-Cited by-同舟云学术

The stochastic nature of action potential backpropagation in apical tuft dendrites

Published:2017-08-01 Issue:2 Volume:118 Page:1394-1414
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Short Shaina M.¹,Oikonomou Katerina D.¹,Zhou Wen-Liang¹,Acker Corey D.²,Popovic Marko A.³,Zecevic Dejan³,Antic Srdjan D.¹⁴⁵

Affiliation:

1. Department of Neuroscience, UConn Health, Farmington, Connecticut

2. Center for Cell Analysis and Modeling, UConn Health, Farmington, Connecticut

3. Department of Cellular and Molecular Physiology, Yale University, New Haven, Connecticut

4. Stem Cell Institute, UConn Health, Farmington, Connecticut

5. Institute for Systems Genomics, UConn Health, Farmington, Connecticut

Abstract

The bAP-Ca2+ signal amplitudes in some apical tuft branches randomly vary from moment to moment. In repetitive measurements, successful AP invasions are followed by complete failures. Passive spread of voltage from the apical trunk into the tuft occasionally reaches the threshold for local Na+ spike, resulting in stronger Ca2+ influx. During a burst of three somatic APs, the peak of dendritic Ca2+ in the apical tuft occurs with a delay of 20-50 ms depending on AP frequency.

Funder

HHS | NIH | National Institute of Mental Health (NIMH)

HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

National Science Foundation (NSF)

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://www.physiology.org/doi/pdf/10.1152/jn.00800.2016

Reference79 articles.

1. Quantitative Assessment of the Distributions of Membrane Conductances Involved in Action Potential Backpropagation Along Basal Dendrites