Behaviorally contingent property of movement-related activity of the primate putamen

Abstract

1. In this study, the movement-related activity of putamen neurons was investigated in behaving monkeys. The objective of the study was to examine whether the activity occurring in phase with body movements is directly related to the movement per se by encoding movement parameters or whether it is dependent on the circumstances in which the movement is performed. 2. Sensorially triggered arm movements were used as a behavioral task. A sequence of three visually triggered repetitive flexion-extensions of the elbow joint across the target were followed by the delivery of a juice reward. 3. There are two classes of putamen cells: type I, with tonic spontaneous discharges (2-7 Hz) and broad extracellularly recorded action potentials, and type II, with very low spontaneous discharge rate (less than 1 Hz). The movement-related phasic discharges occur exclusively in type II cells. 4. The movement-related activity of type II cells is classified into two contrasting types of cells: type IIa that exhibit burst discharges preceding the first movement of a sequence of repetitive arm or orofacial movements but that are almost inactive during succeeding movements, and type IIb that show movement-locked burst discharges with one-to-one correspondence. The somatotopic location of the cells was identified by microstimulation and/or sensory responses to passive somatosensory manipulation of the periphery. 5. The activities of type IIa cells occur with a short and fairly constant latency after the visual trigger stimulus and cease as soon as the sequence of the learned movements is initiated. In the condition in which the monkey attended to the visual trigger stimulus without initiating learned movements and waited for the delivery of juice reward at a fixed time after the stimulus, type IIa cells exhibited slight but consistent phasic discharges after the visual stimulus with short latency. This indicates that the type IIa cells have a visuomovement property. The type IIb cells, on the other hand, have a longer latency of activity after the visual trigger than type IIa cells and do not have the visuomovement property. 6. The type IIa cells change their activity pattern depending on whether the direction of initial movement is predictable before the trigger stimulus or not. 7. The activities of type IIa cells in the arm area of the putamen precede the electromyogram (EMG) of prime mover muscles by greater than 100 ms on average, whereas most type IIb cells are activated after the EMG during a learned arm-movement task.(ABSTRACT TRUNCATED AT 400 WORDS)