Estradiol decreases medium spiny neuron excitability in female rat nucleus accumbens core-Reference-Cited by-同舟云学术

Estradiol decreases medium spiny neuron excitability in female rat nucleus accumbens core

Published:2020-06-01 Issue:6 Volume:123 Page:2465-2475
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Proaño Stephanie B.¹²³,Meitzen John²³⁴^ORCID

Affiliation:

1. Graduate Program in Biology, North Carolina State University, Raleigh, North Carolina

2. W. M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina

3. Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina

4. Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina

Abstract

The present study shows, for the first time, that an estrous cycle-relevant estradiol exposure modulates nucleus accumbens neuron excitability. This evidence provides insight into the neuroendocrine mechanisms by which estradiol cyclically alters neuron properties during the estrous cycle. Overall, these data emphasize the significant influence of hormone action in the brain and especially individual neuron physiology.

Funder

HHS | NIH | National Institute of Mental Health

HHS | NIH | National Institute of Environmental Health Sciences

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00210.2020

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