Affiliation:
1. University of Minnesota, Department of Neuroscience, Minneapolis, Minnesota
Abstract
Animals with a global knockout of the GABAAα1 subunit show a tremor phenotype reminiscent of essential tremor. Here we show that selective knockout of GABAAα1 from Purkinje cells is sufficient to produce a tremor phenotype, although this tremor is less severe than seen in animals with a global knockout. These findings illustrate that the cerebellum can play a key role in the genesis of the observed tremor phenotype.
Funder
University of Minnesota McKnight Land-Grant Professorship Award
University of Minnesota MnDRIVE (Minnesota's Discovery, Research and Innovation Economy) initiative
International Essential Tremor Foundation
HHS | NIH | National Institute of Neurological Disorders and Stroke
Publisher
American Physiological Society
Subject
Physiology,General Neuroscience
Cited by
14 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献