Electrophysiological effects of BDNF and TrkB signaling at type-identified diaphragm neuromuscular junctions-Reference-Cited by-同舟云学术

Electrophysiological effects of BDNF and TrkB signaling at type-identified diaphragm neuromuscular junctions

Published:2023-04-01 Issue:4 Volume:129 Page:781-792
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Mantilla Carlos B.¹²^ORCID,Ermilov Leonid G.²,Greising Sarah M.³^ORCID,Gransee Heather M.¹^ORCID,Zhan Wen-Zhi²,Sieck Gary C.¹²^ORCID

Affiliation:

1. Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States

2. Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States

3. School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, United States

Abstract

Neurotrophin brain-derived neurotrophic factor (BDNF) enhances neuromuscular transmission via activation of tropomyosin-related kinase receptor B (TrkB). Rat phrenic nerve-diaphragm muscle preparations were used to determine the rapid effect of BDNF on synaptic quantal release during repetitive stimulation. BDNF treatment significantly enhanced quantal release at all fiber types. BDNF increased synaptic vesicle cycling (measured using FM4-64 fluorescence uptake); conversely, inhibiting BDNF/TrkB signaling decreased FM4-64 uptake.

Funder

HHS | NIH | National Institute on Aging

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00015.2023

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