Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression-Reference-Cited by-同舟云学术

Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression

Published:2021-05-01 Issue:5 Volume:320 Page:F734-F747
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Ostrosky-Frid Mauricio¹²,Chávez-Canales María³,Zhang Jinwei⁴^ORCID,Andrukhova Olena⁵,Argaiz Eduardo R.¹,Lerdo-de-Tejada Fernando³,Murillo-de-Ozores Adrian⁶⁷,Sanchez-Navarro Andrea¹⁷,Rojas-Vega Lorena⁷,Bobadilla Norma A.¹⁷^ORCID,Vazquez Norma¹,Castañeda-Bueno María⁷^ORCID,Alessi Dario R.⁵,Gamba Gerardo¹²⁷^ORCID

Affiliation:

1. Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico

2. PECEM (MD/PhD), Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico

3. Unidad de Investigación UNAM-INC, Instituto Nacional de Cardiología Ignacio Chávez and Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico

4. Institute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Hatherly Laboratories, Exeter, United Kingdom

5. MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee, United Kingdom

6. Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico

7. Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

Abstract

In this work, we demonstrated that the kidney-specific isoform of WNK1 (KS-WNK1) in the kidney is modulated by dietary K+ and activity of the ubiquitin ligase protein Kelch-like protein 3. We analyzed the role of different amino acid residues of KS-WNK1 in its activity against the NaCl cotransporter and sensitivity to Kelch-like protein 3.

Funder

Consejo Nacional de Ciencia y Tecnología

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

UKRI | Medical Research Council

Universidad Nacional Autónoma de México

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00575.2020

Reference28 articles.