Zn<sup>2+</sup> improves sepsis-induced acute kidney injury by upregulating SIRT7-mediated Parkin acetylation-Reference-Cited by-同舟云学术

Zn²⁺ improves sepsis-induced acute kidney injury by upregulating SIRT7-mediated Parkin acetylation

Published:2024-07-01 Issue:1 Volume:327 Page:F184-F197
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Guo Jun¹^ORCID,Yuan Zhenhui²,Wang Rong²

Affiliation:

1. Department of Critical Care Medicine, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China

2. Department of Critical Care Medicine, Union Jiangbei Hospital, Huazhong University of Science and Technology, Wuhan, People’s Republic of China

Abstract

Zn2+ upregulated Parkin acetylation by repressing sirtuin 7 activity to promote mitophagy and inhibit NLRP3 inflammasome activation and pyroptosis, thus improving sepsis-induced acute kidney injury.

Funder

Ministry of Health of China | Wu Jieping Medical Foundation

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00337.2023

Reference65 articles.

1. Sepsis associated acute kidney injury

2. Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis

3. Pharmacological targets in the renal peritubular microenvironment: Implications for therapy for sepsis-induced acute kidney injury

4. Acute kidney injury in sepsis

5. Inhibition of Phosphoinositide 3-Kinase Gamma Protects Endothelial Cells via the Akt Signaling Pathway in Sepsis-Induced Acute Kidney Injury

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