Formation of the glomerular microvasculature is regulated by VEGFR-3-Reference-Cited by-同舟云学术

Formation of the glomerular microvasculature is regulated by VEGFR-3

Published:2023-01-01 Issue:1 Volume:324 Page:F91-F105
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Donnan Michael D.¹^ORCID,Deb Dilip K.¹,Onay Tuncer¹^ORCID,Scott Rizaldy P.¹^ORCID,Ni Eric²^ORCID,Zhou Yalu¹,Quaggin Susan E.¹^ORCID

Affiliation:

1. Northwestern University Feinberg School of Medicine, Feinberg Cardiovascular and Renal Research Institute, Chicago, Illinois

2. Lake Erie College of Osteopathic Medicine, Greensburg, Pennsylvania

Abstract

Targeting VEGFR-3 in kidney lymphatics has been proposed as a method to treat kidney disease. However, expression of VEGFR-3 is not lymphatic-specific. We demonstrated developmental expression of VEGFR-3 in glomerular endothelial cells, with loss of Vegfr-3 leading to malformation of glomerular capillary loops. Furthermore, we showed that VEGFR-3 attenuates VEGFR-2 activity in glomerular endothelial cells independent of paracrine VEGF-C signaling. Together, these data provide valuable information for therapeutic development targeting these pathways.

Funder

HHS | NIH | NIH Office of the Director

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

American Society of Nephrology

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00066.2022

Reference58 articles.