Resting-state MRI reveals spontaneous physiological fluctuations in the kidney and tracks diabetic nephropathy in rats-Reference-Cited by-同舟云学术

Resting-state MRI reveals spontaneous physiological fluctuations in the kidney and tracks diabetic nephropathy in rats

Published:2024-07-01 Issue:1 Volume:327 Page:F113-F127
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Baldelomar Edwin J.¹^ORCID,Morozov Darya¹,Wilson Leslie D.²,Eldeniz Cihat¹,An Hongyu¹^ORCID,Charlton Jennifer R.³^ORCID,Bauer Adam Q.¹,Keilholz Shella D.⁴^ORCID,Hulbert Monica L.⁵,Bennett Kevin M.¹^ORCID

Affiliation:

1. Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States

2. Division of Comparative Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States

3. Division of Nephrology, Department of Pediatrics, University of Virginia, Charlottesville, Virginia, United States

4. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States

5. Division of Pediatric Hematology/Oncology, Washington University School of Medicine in St. Louis, Missouri, United States

Abstract

This work demonstrates the development and use of resting-state MRI to detect low-frequency, spontaneous physiological fluctuations in the kidney consistent with previously observed fluctuations in perfusion and potentially due to autoregulatory function. These fluctuations are detectable in rat and human kidneys, and the power of these fluctuations is affected by diabetic nephropathy in rats.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

WUSM | Mallinckrodt Institute of Radiology

Washington University School of Medicine in St. Louis

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00423.2023

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