YAP promotes AP-1 expression in tubular epithelial cells in the kidney-Reference-Cited by-同舟云学术

YAP promotes AP-1 expression in tubular epithelial cells in the kidney

Published:2023-06-01 Issue:6 Volume:324 Page:F581-F589
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Liu Yang¹²,Xu Chunhua³,Li Jinhong¹,Zhang Yu²,Wang Xiaohua¹,Wang Yang²,Qin Jinzhong⁴,Zheng Zhihua¹,Xia Yin²^ORCID

Affiliation:

1. Department of Nephrology, Center of Nephrology and Urology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, People’s Republic of China

2. Faculty of Medicine, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, People’s Republic of China

3. Shulan International Medical College, Zhejiang Shuren University, Hangzhou, People’s Republic of China

4. The Key Laboratory of Model Animal for Disease Study of Ministry of Education, Model Animal Research Center, Nanjing University, Nanjing, People’s Republic of China

Abstract

Yes-associated protein (YAP) activation leads to tubular injury, renal inflammation, and fibrosis, but the underlying mechanisms are not fully understood. We now provide genetic evidence that YAP promotes activator protein-1 expression and that Fosl1 is the primary target of YAP in renal tubular cells.

Funder

FHB | Health and Medical Research Fund

MOST | National Natural Science Foundation of China

Research Grants Council, University Grants Committee

Science, Technology and Innovation Commission of Shenzhen Municipality

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00246.2022

Reference23 articles.