Ways of calcium reabsorption in the kidney-Reference-Cited by-同舟云学术

Ways of calcium reabsorption in the kidney

Published:2016-06-01 Issue:11 Volume:310 Page:F1337-F1350
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Moor Matthias B.¹,Bonny Olivier¹²

Affiliation:

1. Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland; and

2. Service of Nephrology, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland

Abstract

The role of the kidney in calcium homeostasis has been reshaped from a classic view in which the kidney was regulated by systemic calcitropic hormones such as vitamin D3 or parathyroid hormone to an organ actively taking part in the regulation of calcium handling. With the identification of the intrinsic renal calcium-sensing receptor feedback system, the regulation of paracellular calcium transport involving claudins, and new paracrine regulators such as klotho, the kidney has emerged as a crucial modulator not only of calciuria but also of calcium homeostasis. This review summarizes recent molecular and endocrine contributors to renal calcium handling and highlights the tight link between calcium and sodium reabsorption in the kidney.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/ajprenal.00273.2015

Reference216 articles.

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3. Proximal tubular NHEs: sodium, protons and calcium?

4. Overexpression of claudin-7 decreases the paracellular Cl– conductance and increases the paracellular Na+ conductance in LLC-PK1 cells

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