Kidney collecting duct-derived vasopressin is not essential for appropriate concentration or dilution of urine-Reference-Cited by-同舟云学术

Kidney collecting duct-derived vasopressin is not essential for appropriate concentration or dilution of urine

Published:2024-06-01 Issue:6 Volume:326 Page:F1091-F1100
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Zuchowski Yvonne¹^ORCID,Carty Joshua S.¹,Trapani Jonathan B.²^ORCID,Watts Jason A.³^ORCID,Bock Fabian¹⁴^ORCID,Zhang Mingzhi¹⁴,Terker Andrew S.¹⁴^ORCID,Zent Roy¹⁴⁵^ORCID,Delpire Eric⁶^ORCID,Harris Raymond C.¹⁴⁵⁷,Arroyo Juan Pablo¹⁴⁷⁸^ORCID

Affiliation:

1. Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States

2. Vanderbilt University School of Medicine, Nashville, Tennessee, United States

3. Epigenetics and Stem Cell Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States

4. Vanderbilt Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, Tennessee, United States

5. Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, Tennessee, United States

6. Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States

7. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States

8. Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, United States

Abstract

Hypothalamic vasopressin is required for appropriate urinary concentration. However, whether collecting duct-derived vasopressin is involved remains unknown. We developed a novel transgenic mouse model to induce tissue-specific deletion of vasopressin and showed that collecting duct-derived vasopressin is not required to concentrate or dilute urine.

Funder

ASN Foundation for Kidney Research

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute of Environmental Health Sciences

HHS | National Institutes of Health

Robert Wood Johnson Foundation

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00057.2024

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