Effect of metabolic acidosis on renal response to parathyroid hormone in phosphorus-deprived rats

Author:

Beck N.

Abstract

Both metabolic acidosis and phosphorus (Pi) deprivation have been shown to alter not only renal Pi metabolism independent of parathyroid hormone (PTH), but also the phosphaturic response to PTH. In the present studies, we examined the interaction between metabolic acidosis and Pi deprivation on renal handling of Pi in an animal model in which metabolic acidosis was superimposed on 3 days of dietary Pi deprivation. The effect of metabolic acidosis was evaluated after acute (for 3 h) and chronic (for 3 days) administration of HCl. In Pi-deprived and thyroparathyroidectomized rats, chronic acidosis increased both plasma Pi and the basal fractional excretion of Pi (FEPi). Furthermore, chronic acidosis partially restored the phosphaturic response to PTH, which was totally absent in nonacidotic Pi-deprived rats. These effects metabolic acidosis were not demonstrable in acutely acidotic animals. Determination of PTH-dependent cAMP generation and cAMP-dependent protein kinase activation revealed that neither of these parameters was altered by chronic metabolic acidosis in vivo. These results show that in Pi-deprived rats chronic metabolic acidosis induced by HCl administration further modifies the renal handling of Pi associated with Pi deprivation. Further, the renal interaction between acidosis and Pi deprivation is at a step (or steps) after cAMP generation and protein kinase activation.

Publisher

American Physiological Society

Subject

Physiology

Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3