Expression of leptin receptor in renal tubules is sparse but implicated in leptin-dependent kidney gene expression and function-Reference-Cited by-同舟云学术

Expression of leptin receptor in renal tubules is sparse but implicated in leptin-dependent kidney gene expression and function

Published:2023-06-01 Issue:6 Volume:324 Page:F544-F557
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Kim Young Chul¹²,Fattah Hadi¹²,Fu Yiling²,Nespoux Josselin²,Vallon Volker¹²³^ORCID

Affiliation:

1. Division of Nephrology and Hypertension, Department of Medicine, University of California-San Diego, La Jolla, California, United States

2. Veterans Affairs San Diego Healthcare System, San Diego, California, United States

3. Department of Pharmacology, University of California-San Diego, La Jolla, California, United States

Abstract

This study provides new insights into kidney gene expression of leptin receptor splice variants, leptin-sensitive kidney gene expression, and the role of the leptin receptor in renal tubular cells for the response to diet-induced hyperleptinemia and obesity including albuminuria.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute on Aging

U.S. Department of Veterans Affairs

University of California, San Diego

Janssen Pharmaceuticals

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00279.2022