The influence of intermittent hypoxia, obesity, and diabetes on male genitourinary anatomy and voiding physiology-Reference-Cited by-同舟云学术

The influence of intermittent hypoxia, obesity, and diabetes on male genitourinary anatomy and voiding physiology

Published:2021-07-01 Issue:1 Volume:321 Page:F82-F92
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Abler Lisa L.¹²,O’Driscoll Chelsea A.¹²,Colopy Sara A.³,Stietz Kimberly P. Keil¹,Wang Peiqing³,Wang Zunyi³,Hartmann Faye⁴,Crader-Smith Stephanie M.¹,Oellete Jonathan N.¹,Mehta Vatsal¹,Oakes Steven R.¹,Grimes Matthew D.⁵,Mitchell Gordon S.⁶,Baan Mieke⁷⁸,Gallagher Shannon J.⁷⁸,Davis Dawn B.⁷⁸,Kimple Michelle E.⁷⁸,Bjorling Dale E.²³,Watters Jyoti J.¹,Vezina Chad M.¹²^ORCID

Affiliation:

1. Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin

2. University of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O’Brien Center for Benign Urologic Research, Madison, Wisconsin

3. Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin

4. Microbiology Laboratory, UW Veterinary Care, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin

5. Department of Urology, University of Wisconsin-Madison, Madison, Wisconsin

6. Department of Physical Therapy and McKnight Brain Institute, University of Florida, Gainesville, Florida

7. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin

8. William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin

Abstract

Metabolic syndrome and obstructive sleep apnea are common in aging men, and both have been linked to urinary voiding dysfunction. Here, we show that metabolic syndrome and intermittent hypoxia (a manifestation of sleep apnea) have individual and combined influences on voiding function and urogenital anatomy in male mice.

Funder

HHS | NIH | NIH Office of the Director

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | National Center for Research Resources

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute of Environmental Health Sciences

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00112.2021