Effect of the DASH diet on the sodium-chloride cotransporter and aquaporin-2 in urinary extracellular vesicles-Reference-Cited by-同舟云学术

Effect of the DASH diet on the sodium-chloride cotransporter and aquaporin-2 in urinary extracellular vesicles

Published:2024-06-01 Issue:6 Volume:326 Page:F971-F980
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Bielopolski Dana¹^ORCID,Musante Luca²^ORCID,Hoorn Ewout J.³^ORCID,Molina Henrik⁴,Barrows Douglas⁵,Carrol Thomas S.⁵,Harding Michael A.⁶,Upson Samantha⁶^ORCID,Qureshi Adam¹,Weder Max M.⁷^ORCID,Tobin Jonathan N.¹⁸,Kost Rhonda G.¹^ORCID,Erdbrügger U.⁶

Affiliation:

1. The Rockefeller University Center for Clinical and Translational Science, New York, New York, United States

2. School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States

3. Division of Nephrology and Transplantation, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

4. Proteomics Resource Center, Rockefeller University, New York, New York, United States

5. Bioinformatics Resource Center, Rockefeller University, New York, New York, United States

6. Division of Nephrology, Department of Medicine, University of Virginia at Charlottesville, Charlottesville, Virginia, United States

7. Division of Pulmonology, Department of Medicine, University of Virginia at Charlottesville, Charlottesville, Virginia, United States

8. Clinical Directors Network, New York, New York, United States

Abstract

Numerous studies link DASH diet to lower blood pressure, but its mechanism is unclear. Urinary extracellular vesicles (uEVs) offer noninvasive insights, potentially replacing tissue sampling. Transitioning to DASH diet alters kidney transporters in our stage 1 hypertension cohort: AQP2 decreases, NCC increases in uEVs. This aligns with increased urine volume, reduced sodium reabsorption, and blood pressure decline. Our data highlight uEV protein changes as diet markers, suggesting some uEVs may function as waste pathways. We analyzed larger EVs alongside small EVs, and NCC in immunoblots across its molecular weight range.

Funder

American Diabetes Association

EC | ERC | HORIZON EUROPE European Research Council

HHS | NIH | National Center for Advancing Translational Sciences

National Kidney Foundation

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00274.2023

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